Glucose transporters (GLUT and SGLT): expanded families of Glucose transporter proteins: Diabetes mellitus: Adipose tissue: Muscle: Sugar transport. Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans. Sodium-dependent glucose cotransporters are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the.
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Six of these membrane spanning helices are believed to bind together in the membrane to create a polar channel in the center through which glucose can traverse, with the hydrophobic regions on the outside of the channel adjacent to the fatty acid tails of the membrane. GLUT 1 is highly conserved. Biochimica glikosa Biophysica Acta. Molecular Biology of the Cell.
Glucose 6-phosphatase – Wikipedia
This article incorporates text available under the CC BY 4. The hydrolysis of glucosephosphate begins with a nucleophilic attack on the sugar-bound phosphate by His resulting in the formation of a phosphohistidine bond glykosa the degradation of a carbonyl. Click on genes, vlukosa and metabolites below to link to respective articles. The key point here was ‘flux coupling’, the cotransport of sodium and glucose in the apical membrane of the small intestinal epithelial cell.
Annual Review of Nutrition.
This hypothesis was rapidly tested, refined, and extended [to] encompass the active transport of a diverse range of molecules and ions into virtually every cell type. Crane in was the first to formulate the cotransport concept to explain active transport . From Wikipedia, the free encyclopedia. Members of the GLUT family of glucose uniporters then transport the glucose across the basolateral membrane, and into the peritubular capillaries.
Other variable features may include seizures, migraine headaches, and ataxia. Views Read Edit View history.
Glucose 6-phosphatase EC 3. Molecular and Cellular Biology portal. In humans, there are three isozymes of the catalytic subunit: The Journal transpoorter Biological Chemistry. In Augustin Prague, Robert K.
Sodium-glucose transport proteins
The phospho-intermediate produced by the reaction between His and the phosphate group is then broken by a hydrophilic attack; after the addition of another hydroxide and the decomposition of a transportrr, the carbonyl is reformed kicking off the electrons originally donated by the His residue thereby creating a free phosphate group and completing the hydrolysis.
Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator.
GLUT1 – Wikipedia
Retrieved from ” https: Membrane proteinscarrier proteins: Expression levels of GLUT1 in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. Another mutation, ARGCYS, has been shown to cause Dystonia 9 DYT9an autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia.
Aspergillus nuclease S1 Micrococcal nuclease. Onset of seizuresusually characterized by apneic episodesstaring spells, and episodic eye movementsoccurs within the first 4 months of life. This page was last edited on 2 Novemberat The glucose transporter of erythrocytes called GLUT1 to distinguish it from related glucose transporters in other tissues is a type III integral protein with 12 hydrophobic segments, each of which is believed to form a membrane-spanning helix. The dyskinesia involves transient abnormal involuntary movementssuch as dystonia and choreoathetosisinduced by exercise or exertion, and affecting the exercised limbs.
Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption.